GONAL-f is a medicine containing follitropin alfa, obtained by special DNA recombination techniques. Folitropin alfa belongs to a group of hormones called gonadotrophins, which are involved in the normal control of reproduction.
GONAL-f may be used to induce ovulation in women who haven’t ovulated and haven’t responded to clomiphene citrate treatment and Gonal-f cost is very reasonable than that of other treatments.
- GONAL-f is used to induce the development of multiple follicles (and as a result of several eggs) for women undergoing assisted reproduction techniques, such as in vitro fertilization, intra-fallopian gamete transfer or intra-fallopian transfer of zygotes.
- In women without ovulation due to poor secretion of fertility hormones (FSH and LH) by the pituitary gland, GONAL-f is used together with another hormone called lutropin alfa (recombinant human luteinizing hormone) to produce ovulation.
- GONAL-f is used in combination with other drugs, human chorionic gonadotrophin (hCG), to produce sperm in men who are infertile due to hormone deficiency.
Do not use GONAL-f:
- If you have an allergy to follicle-stimulating hormone (FSH) or any of the other components in Gonal-f, you should not use it.
- If you have a tumor of the hypothalamus or pituitary gland, you should not use Gonal-f
- If you have a rise in the size of your ovary or the existence of fluid sacs in your ovaries (ovarian cysts) of unknown origin, do not take Gonal-f.
- Also is you face unexplained vaginal bleeding
- If you have cancer of the ovaries, uterus or breast
- Gonal-f should not be used if you have a disease that renders a normal pregnancy difficult, such as ovarian failure (early menopause) or a sexual organ abnormality.
Right Dosage of Gonal-F
The GONAL-f dosage is the same as the FSH dose for urine FSH. GONAL-f has been clinically evaluated, and it appears that daily dosages, administration protocols, and treatment monitoring methods should not change from those presently utilised for medications containing urinary FSH.
GONAL f 450 needed a lower cumulative dosage and a shorter treatment time on average than urinary FSH, according to comparative clinical studies. As a result, a lower total dosage of GONAL-f is recommended than the standard dose of urinary FSH, not only to maximise follicular growth but also to reduce the risk of undesired ovarian hyperstimulation.
GONAL-f is a daily injection that can be administered in a series of doses. Treatment for menstruating women should begin within the first seven days of the menstrual cycle.
A typical treatment begins with 75-150 IU FSH daily and is preferably raised by 37.5 or 75 IU at 7-day intervals or ideally 14 days if necessary to get a satisfactory but not excessive response. Treatment must be tailored to the patient’s unique response, as determined by ultrasonography and/or oestrogen secretion measurements. 225 IU FSH is the highest daily dosage that should generally be avoided. If a patient does not react satisfactorily after four weeks, the cycle should be stopped and further assessments conducted, following which therapy might be resumed at greater starting dosages than in the previous cycle.